Diet pills are extremely popular for many individuals trying to lose weight, though the success of most of the pharmaceutical weight loss pills has been dampened by their safety profile. Many of the popular diet pills, like fenfluramine, dexfenfluramine, and sibutramine, have been removed or are in danger of being removed from the market due to safety concerns.
According to a
new weight loss study published in the
New England Journal of Medicine, a new drug, lorcaserin, successfully helps with weight loss without the safety concerns of previous diet pills. In this study, investigators randomly assigned over 3,000 overweight or obese adults to receive either a lorcaserin diet pill or a placebo pill twice daily for 1 year. After completion of the first year, individuals who had received the lorcaserin were re-assigned to either continue taking lorcaserin or take the placebo pill for a second year. All study volunteers received regular counseling to exercise moderately 30 minutes each day and to consume 600 fewer Calories per day. Weight loss was examined after the first year and weight maintenance was determined after the second year. The study investigators reported that:
- Volunteers taking lorcaserin lost 13 lbs on average after 1 year, while volunteers taking the placebo pill lost only 5 lbs on average.
- 47.5% of volunteers taking lorcaserin lost more than 5% of their body weight compared to only 20% of volunteers taking the placebo pill.
- During the second year of the study, 68% of the study subjects taking lorcaserin maintained their weight loss for a year. Only 50% of the subjects taking the placebo pill managed to maintain their weight loss after a year.
- Side effects of lorcaserin use were considered mild and included headache, dizziness, and nausea. Furthermore, use of lorcaserin was not linked to increases in heart valve problems.
At first blush, these look like excellent results. Study volunteers taking this new diet pill lost weight, maintained their weight loss, and, compared to control subjects, experienced no differences in serious side effects. However, I keep coming back to that average 13-lb weight loss. Volunteers in the lorcaserin group exercised 30 minutes per day, consumed 600 fewer calories per day than they needed, and took lorcaserin twice daily, all of which resulted in an average loss of 13 lbs in one year. If you look at that number another way, that would be equal to an average of 1/4 lb per week. How many of us would be happy losing only 1/4 lb per week?
According to an article on the Mayo Clinic website,
cutting 500 calories per day (3,500 calories per week) from your typical diet will result in losing 1 lb per week. The volunteers in this study were supposed to consume 600 calories per day (4,200 calories per week) less than their energy needs and yet they only lost 1/4 lb per week on average. This could suggest that either the study volunteers weren't exercising and dieting according to the instructions or the diet pill wasn't as effective as it appears. A
previous study of this same diet pill showed that it could help with weight loss in individuals following their regular diet and activity plans, suggesting that diet and exercise might not be needed when taking this diet pill.
Since this drug works by decreasing food intake, it might be possible that weight loss could be achieved without additional dieting and exercise; however, an average weight loss of 13 lbs per year does not seem as effective as diet and exercise alone can be. For example, dieters lost nearly 400% more weight on my diet's eating and
physical activity plan when compared to another study of dieters who used a leading weight loss diet pill plan. You can lose more weight in less time on my
diet plan without using diet pills; however, if with your doctor’s consent you choose to use a diet pill, my eating and physical activity plan is the perfect complement for the best results.