Sucralose is one of the world's most popular artificial sweeteners; however, controversies regarding its effects on body weight are commonly discussed in the media. This is because some animal studies have reported that sucralose consumption increases glucose absorption and weight gain. However, a new study suggests that the results seen in animal studies do not apply to humans.
In this new study published online in the British Journal of Nutrition, researchers investigated the effect of sucralose consumption in ten human volunteers. Volunteers received an infusion of either (1) a sucralose solution or (2) a saline solution control. Changes in blood glucose and glucagon-like peptide-1, an appetite-related hormone, were examined over a 2 hour period after treatment infusions. The results of this human clinical trial showed that infusion of sucralose did not affect levels of glucose or glucagon-like peptide-1.
According to a recent press release, the study researchers suggested that the lack of an effect of sucralose on glucose absorption observed in this human trial is likely due to species differences in how glucose is transported. The predominant glucose transporter in rodents is present in much lower levels in human beings, perhaps explaining why sucralose does not appear to have a negative effect on blood sugar and body weight in people. The International Food Information Council Foundation has an excellent publication on sucralose, Everything You Need To Know About Sucralose, that is free to download if you want to read more about sucralose.
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